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We are committed to helping advance COVID-19 studies quickly and effectively.COVID-19 RESOURCES & UPDATES

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COVID-19 Resources & Updates

Clinical Trials Ontario is committed to helping advance COVID-19 research and clinical trials as quickly and effectively as possible by connecting the clinical trials community, sharing relevant information, and getting studies off the ground efficiently. On this page, you will find helpful resources, relevant news items, Health Canada approved COVID-19 studies, and a list of COVID-19 trials using CTO Stream.

CTO can help you move COVID-19 studies forward quickly

Through CTO’s programming, CTO Stream, the Trial Site Network, and QuickSTART, we can help identify collaborators across the province and assist in managing study start-up at each of these centers. Read more about how we can help you move forward, faster here. 

News and Resources

Active Research Projects 

COVID-19 Clinical Trials in CTO Stream

This list includes COVID-19 clinical trials, interventions or observational studies within the CTO Stream program. This list is intended to facilitate connections between the clinical trials community to accelerate COVID-19 research in Ontario. If you would like more information on these trials, please email info@ctontario.ca.

A Multi-centre, Adaptive, Randomized, Open-label, Controlled Clinical Trial of the Safety and Efficacy of Investigational Therapeutics for the Treatment of COVID-19 in Hospitalized Patients (CATCO)

COVID-19 Ring-based Prevention trial with Lopinavir/ritonavir (CORIPREV LR)

Anti-Coronavirus Therapies to prevent COVID-19 progression (ACT) Trial

How are you coping? Assessing the psychological, social, and economic impacts of an emerging pandemic (C19 Survey)

Protecting Frontline Health Care Workers from COVID-19 with Hydroxychloroquine Pre-exposure Prophylaxis: A Randomized, Placebo-controlled Multi-Site Trial in Toronto, Canada (HEROs Trial)

Altered sense of smell and distorted taste as cardinal symptoms of COVID-19 using subjective and self-reported objective measures

Post-exposure Prophylaxis or Preemptive Therapy for SARS-Coronavirus-2: A Pragmatic Randomized Clinical Trial (COVID-19 PEP RCT - Canada)

ExtraCorporeal Membrane Oxygenation for 2019 novel Coronavirus Acute Respiratory Disease (The ECMOCARD Study)

RUX-COVID: A single arm open-label clinical study to investigate the efficacy and safety of RUXolitinib for the treatment of COVID-19 pneumonia

Risk of death or respiratory failure in patients with COVID-19 who received an ACE inhibitor, ARB, or NSAID: An International Multicentre Cohort study [COVID-ACE/ARB/NSAID] (COVIDACE)

A Research Platform to Screen and Protect Healthcare Workers (U-DEPLOY: RESPECT)

A Randomized, Open-Label Trial of CONvalescent Plasma for Hospitalized Adults With Acute COVID-19 Respiratory Illness (CONCOR-1)

A Research Platform to Screen Patients in Oncology and Assess Impact (U-DEPLOY: RESPONSE)

National CVA COVID Study

Pandemic Response Biobank for Coronavirus Samples (U-Deploy: PRESERVE)

Progression and predictors of myocardial injury in resolved COVID-19 patients (COVID-19)

REMAP-CAP (Randomized, Embedded, Multifactorial, Adaptive Platform Trial for Patients with Community Acquired Pneumonia)

Awake Prone Position in Hypoxemic Patients with Coronavirus Disease 19 (COVI-PRONE): A Randomized Clinical Trial

Post discharge after surgery Virtual Care with Remote Automated Monitoring technology (PVC-RAM) Trial

Randomized clinical trial of Acai Palm Berry extract as an intervention in patients diagnosed with COVID-19 (Palm Berry extract in COVID-19 patients)

A National Registry to address knowledge gaps in emergency management for patients presenting during the COVID-19 pandemic (Canadian Emergency Department COVID-19 Registry)

Assessing the mother-to-infant transmission capabilities of COVID-19 infection among pregnant women in Ontario, Canada (The COVID-19 Ontario Pregnancy Event (COPE) Network)

Hearing and Supporting the Healthcare Workers: Mental Health Outcomes in Healthcare Workers during COVID-19 (MHW-COVID-19)

The Ontario COVID-19 Prospective Cohort Study

Covidfree@home

Identifying atypical presentations of COVID-19 in older adults to enhance screening and detection (COVID-AP)

SedAting With Volatile Anesthetics Critically Ill COVID-19 Patients in ICU (SAVE-ICU trial): Effects On Ventilatory Parameters And Survival.

Clinical course of COVID-19 positive cancer patients on or recently ceased checkpoint inhibitor therapy

Prone positioning for patients on general medical wards with COVID-19: A multicenter pragmatic randomized trial [COVID-PRONE]

Surveillance of Short- and Long-term Outcomes of Infants Born to COVID-19 Positive Mothers: A Prospective Epidemiological Study (COVID19outcomes)

Coagulopathy of COVID-19: A Pragmatic Randomized Controlled Trial of Therapeutic Anticoagulation versus Standard Care as a Rapid Response to the COVID-19 Pandemic (RAPID COVID COAG)

COVID-19: Impact on Adults with Mental Health Problems (CovidIAMH)

Healthcare Worker Seroprevalence of anti-SARS-CoV-19 Antibodies

ANTITHROMBOTIC THERAPY TO AMELIORATE COMPLICATIONS OF COVID-19 (ATTACC)

COVID-19 Virtual Care at Home

Use of High Dose Inhaled Nitric Oxide in Patients Admitted with COVID-19 (High Dose iNO for COVID-19)

Interferon Lambda for Immediate Antiviral therapy at Diagnosis (ILIAD): A phase II randomized, open-label, multicenter, trial to evaluate the effect of peginterferon lambda for the treatment of COVID-19

Automated Oxygen Titration, Monitoring and Weaning in patients with infectious pneumonia requiring oxygen impact on the number of interventions for healthcare workers. An innovative device to manage patients with COVID-19 pneumonia COVID study (Closed-Loop Oxygen to Verify that healthcare workers Interventions Decrease during pneumonia)

Analysis of Ocular Fluid Specimens in Patients with COVID-19

Impact of COVID-19 on Surgical Care in Ontario- Identification of Gaps in Essential Procedures and Strategies to Enhance Surgical Care Delivery (Mitigating the impact of COVID-19 on Surgical Care Delivery)

Lessening Organ Dysfunction with VITamin C-COVID (LOVIT-COVID)

Lessening Organ Dysfunction with VITamin C (LOVIT)

COVID-19: Risks to Mental Health in Seniors (CRiMHS)

Seroprevalence of COVID-19 among African Canadians: Clinical and Epidemiological Correlates (seroMARK Study)

Impact of COVID-19 pandemic on time to retinal detachment repair – a multicenter retrospective comparative interrupted time-series (COVID RD-REPAIR)

A prospective randomized trial of prone positioning versus usual care for patients with do-not-intubate goals of care and hypoxemic respiratory failure during the coronavirus SARS-CoV-2 (COVID-19) pandemic. (CORONA)

The GEMINI Hospital Cohort Study

A Multicentric Collaboration to Evaluate Quantitative Serological Assays for SARS-CoV-2 (CONQUER)

InterferOn lambDa therapY for Symptomatic SARS-CoV-2 EarlY in infection (ODYSSEY): A phase III randomized, double-blind, placebo-controlled, multicenter, trial to evaluate the effect of peginterferon lambda for the treatment of COVID-19 (ODYSSEY)

Understanding the Process of Critical Care Trial Implementation in a Pandemic Situation (ICU Pandemic Trials)

Preoperative and postoperative cognitive trajectories in older patients with deferred surgery due to the COVID-19 emergency: a prospective cohort study. (Co-TELE-SURGE)

The RAPID COVID study – Application of Point-of-Care COVID-19 Testing to Optimize Patient Care, Resource Allocation and Safety for Frontline Staff (The RAPID COVID-19 Point of Care)

COVID-19: comprehensive biomarker analysis for prediction of clinical course and patient treatment outcomes (COVID-BEACONS)

Semaglutide to reduce Myocardial injury in PATIents with COVID-19 (SEMPATICO)

Antibody serum panel from humans to evaluate rapid diagnostic equipment specialized in detecting SARS-CoV-2 (APHERESIS)

Co-designing and Pilot Testing an Infographic to Support Patients/Families through the REMAP-CAP Consent Process (REMAP-CAP Consent Infographic)

A Phase 2/3, Two-Part, Open-Label, Dose-Escalation, Age De-escalation and Randomized, Observer-Blind, Placebo-Controlled Expansion Study to Evaluate the Safety, Tolerability, Reactogenicity, and Effectiveness of mRNA-1273 SARS-CoV-2 Vaccine in Healthy Children 6 Months to Less Than 12 Years of Age

COVID-19 Vaccine-induced Inflammatory Heart Disease Prevalence Registry (COVID-VIHPR)

COVID-19 Vaccine Immunogenicity and Safety in Immunodeficient Patients – VISID study

Experiences and opinions of bereaved family caregivers and healthcare providers regarding the impact of COVID-19 on cancer care at the end of life: A Qualitative Study (CIHR COVID Qual Project)

A Multi-Center Evaluation of Buccal Swabs with the Abbott ID NOWTM COVID-19 for Point-of-Care Detection SARS-CoV-2 in Pediatric Emergency Departments (PERC-Health Canada Abbott ID NOW COVID-19 Buccal Swab Evaluation Study)

Pregnant and Lactating Individuals & Newborns COVID-19 Vaccination (PLAN-V) Prospective Cohort Study

The impact of COVID-19 on persons with HIV in Canada: Data from the HIV/HCV co-infection/CCC (CTN 222) and HIV aging cohorts (CTN 314). (CHANGE/CCC COVID-19 Substudy)

COV-IMMUNO - A RANDOMIZED, PHASE III TRIAL OF IMMUNIZATION WITH IMM-101 VERSUS OBSERVATION FOR THE PREVENTION OF SEVERE RESPIRATORY AND COVID-19 RELATED INFECTIONS IN CANCER PATIENTS AT INCREASED RISK OF EXPOSURE (IC.8)

IMPACT OF RESTRICTED VISITATION POLICIES IN THE COVID-19 PANDEMIC ON PARENTS OF CRITICALLY ILL CHILDREN (COVID-19 VISITATION POLICIES)

LIVING WITH CANCER IN THE TIME OF COVID-19: A COHORT STUDY OF THE IMPACT OF COVID-19 PANDEMIC ON CANCER PATIENTS DURING TREATMENT AND SURVIVORS (SC.27)

An Analysis of Emergency Department Self-Harm Presentations during the COVID-19 Pandemic

Third Dose of Moderna mRNA-1273 COVID-19 Vaccine in Residents of Long-Term Care Facilities

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