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Streamlined Research Ethics Review

streamlined research ethics reviewClinical Trials Ontario is supporting the movement for a single provincial ethics review for multi-site research in Ontario. The CTO streamlined approach provides an efficient way to conduct research ethics reviews and make research studies more efficient and cost-effective. Our Ontario-built online system enables all research sites participating in a multi-site research study to undergo a single ethics review rather than separately applying to their local research ethics boards. This reduces the time and labour required to obtain research ethics approval.

How It Works

How It Works

With CTO Stream, research teams can submit a provincial application for ethics approval on behalf of all participating sites in Ontario.

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CTO Stream Digital Platform

CTO Stream Digital Platform

CTO Stream is a web-based electronic platform for coordinating research ethics reviews. Log into your CTO Stream account here.

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REB Qualification Program

REB Qualification Program

CTO Qualified research ethics boards can provide ethical review and oversight for multiple sites participating in the same research study.

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Webinars and Training

Webinars and Training

New to CTO Stream? We have resources available to users of our system, including training webinars, manuals, quick guides and videos.

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Participating Sites

Participating Sites

More than 100 hospitals and research sites are participating in CTO’s streamlined research ethics review system – and counting.

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Qualified REBs

Qualified REBs

These research ethics boards (REBs) have achieved CTO Qualification status and can support a single research ethics review through CTO Stream.

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REB Council

REB Council

The CTO Research Ethics Board (REB) Council provides advice and guidance to CTO on our streamlined research ethics review and related issues.

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Tools and Resources

Tools and Resources

Find consent form templates, application forms, fee structures and other resources to support REB and site participation in CTO Stream.

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CTO Stream By-The-Numbers

CTO Impact & Milestones

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