Tools and Resources
CTO Stream Support
In order to streamline support requests and better serve you, we utilize a support ticket system. Visit support.ctontario.ca to submit a ticket.
CTO Informed Consent Form Templates
The CTO templates are available in English and French. Based on the type of research you are submitting, select the appropriate template and be sure to follow all the instructions listed on the first page of the template.
Important Notice – Mandatory Use of CTO ICF Template as of May 1, 2019
| Study Type | Corresponding CTO Informed Consent Form Template |
|---|---|
| Clinical Trial | Clinical Trial Informed Consent Template – English |
| Observational Study | Observational Informed Consent Template – English |
| Pediatric Research Study | Assent Template for Pediatric Clinical Research – English |
Application Form Templates
Clinical Trials Form Templates
- Provincial Initial Application/CHEER Initial Application
- Provincial Amendment/CHEER Amendment
- Provincial Reportable Event/CHEER Reportable Event
- Provincial Continuing Review/CHEER Continuing Review
- Provincial Study Closure/CHEER Study Closure
- Centre Initial Application
- Centre Amendment
- Centre Reportable Event
- Centre Continuing Review
- Centre Study Closure
Observational Form Templates
- Provincial Initial Application/CHEER Initial Application
- Provincial Amendment/CHEER Amendment
- Provincial Reportable Event/CHEER Reportable Event
- Provincial Continuing Review/CHEER Continuing Review
- Provincial Study Closure/CHEER Study Closure
- Centre Initial Application
- Centre Amendment
- Centre Reportable Event
- Centre Continuing Review
- Centre Study Closure
Fee Structure and Distribution
CTO Streamlined Research Ethics Review Fees for Industry Sponsored Clinical Trials (Download)
CTO Streamlined Research Ethics Review System Breakdown of Fees Distribution for Industry Sponsored Clinical Trials.
Effective: February 25, 2015
| Fees Charged to Study Sponsor | Number of Research Sites Participating in the Study | Distribution of Fees | ||
| REB of Record Fee per Study | Total Site Participation Fees* ($500/site) | Fees Retained by CTO | ||
| $3,000 + HST per research site | 2 | $5,000 | $1,000 | – |
| 3 | $5,250 | $1,500 | $2,250 | |
| 4 | $5,500 | $2,000 | $4,500 | |
| 5 | $5,750 | $2,500 | $6,750 | |
| $2,000 + HST per research site after first 5 sites | 6 | $6,000 | $3,000 | $8,000 |
| 7 | $6,250 | $3,500 | $9,250 | |
| 8 | $6,500 | $4,000 | $10,500 | |
| 9 | $6,750 | $4,500 | $11,750 | |
| 10 | $7,000 | $5,000 | $13,000 | |
| $1500 + HST per research site after first 10 sites | 11 | $7,250 | $5,500 | $13,750 |
| 12 | $7,500 | $6,000 | $14,500 | |
| 13 | $7,750 | $6,500 | $15,250 | |
| 14 | $8,000 | $7,000 | $16,000 | |
| 15 | $8,250 | $7,500 | $16,750 | |
| 16 | $8,500 | $8,000 | $17,500 | |
| 17 | $8,750 | $8,500 | $18,250 | |
| 18 | $9,000 | $9,000 | $19,000 | |
| 19 | $9,250 | $9,500 | $19,750 | |
| 20 | $9,500 | $10,000 | $20,500 | |
* Site participation fees are intended to provide support for the ongoing operations of Research Ethics Boards (REBs) at institutions. Site participation fees will only be disbursed to sites that have an internal and/or institutional REB supported by their institution.
Note: Study sponsors will be charged an additional fee of $500 + HST per major amendment, after the first 3 major amendments, the full amount of which will be disbursed to the host institution of the REB of Record.
Participation Agreement
The Participation Agreement provides the framework for allowing sites to delegate ethical review and oversight for research conducted under its auspices, to a CTO Qualified board. This delegation occurs on a study-by-study basis, meaning that a site can choose whether to use CTO Stream for each individual study.
If you have questions about the Participation Agreement, please contact the CTO Help Desk at streamline@ctontario.ca
CTO REB Qualification Program
Master Services Agreement
For Sponsors/CROs who require a service agreement in order to issue payments to CTO for REB fees, CTO has developed the following Master Service Agreement template.
N2/CAREB-ACCER Observational Health REB SOPs
The Standard Operating Procedures for REBs that review Observational Health Research (Observational Health SOPs) were developed for REBs that do not normally review regulated clinical trials, and therefore do not need to comply with the more prescriptive standards and regulations such research requires. These SOPs have been designed for use by REBs that may review non-clinical trial biomedical, population and global health, and socio-behavioural research. They may also be used for REBs that review other types of research that involve human participants such as scholarship on teaching and learning, management, and humanities. The Observational Health SOPs, which use the CAREB/N2 SOPs as the foundation, have been developed to be compliant with TCPS only. They are meant to be flexible in style, as the TCPS is, with allowances for institutions to make changes as needed (so long as they remain compliant with TCPS). Guidelines will be developed on topics related to the SOPs, such as methods of consent, privacy legislation, and conflicts of interest.
For any questions or suggestions for improvement, please contact Rachel Zand.
- Glossary of Terms
- SOP 101 Authority and Purpose
- SOP 102 Research Requiring REB Review
- SOP 103 Training and Education
- SOP 104 Management of REB Office Personnel
- SOP 105A Conflicts of Interest REB Members and REB Office Personnel
- SOP 105B Conflicts of Interest Researcher
- SOP 105C Conflicts of Interest Organization
- SOP 106 Signatory Authority
- SOP 107 Use and Disclosure of Personal Information
- SOP 108 Standard Operating Procedures Maintenance
- SOP 109 Addendum for US Regulated Research
- SOP 201 Composition of the REB
- SOP 202 Management of REB Membership
- SOP 203 Duties of REB Members
- SOP 204 REB Office Personnel Serving as REB Members
- SOP 301 REB Submission Requirements and Document Review
- SOP 302 REB Meeting Administration
- SOP 303 Document Management
- SOP 401 Delegated Review
- SOP 402 REB Review Decisions
- SOP 403 Initial Review Criteria for REB Approval
- SOP 404 Ongoing REB Review Activities
- SOP 405 Continuing Review
- SOP 406 Research Completion
- SOP 407 Suspension or Termination of REB Approval
- SOP 408 Course-Based Review
- SOP 501 REB Review During Publicly Declared Emergencies
- SOP 601 Communication Researcher
- SOP 602 Communication Research Participants and Public
- SOP 701 Free and Informed Consent
- SOP 801 Researcher Qualifications and Responsibilities
- SOP 901 Quality Assurance Activities
- SOP 902 NonCompliance
- SOP Table of Contents
- Table of Concordance
N2/CAREB-ACCER REB SOPs
To access REB SOPs that are specific to ethics boards that review health sciences research and are compliant with applicable Canadian and US regulatory, and ethics guidance criteria, please visit the CAREB/ACCER website using the link below.
N2/CAREB-ACCER REB SOPs – Canadian Association of Research Ethics Boards