Through the development of resources and tools, we are working to enhance clinical trials in Ontario and beyond. On this page, you’ll find a wide range of materials catered to various needs. Researchers can delve into training on CTO’s digital platforms and strategies for engaging with patients and trial participants, while the general public will find tools to locate trial opportunities and understand what to anticipate as a trial participant. Industry professionals can discover ways to facilitate connections and collaborations in Ontario’s clinical trial landscape.
CTO Stream is a web-based platform that allows multiple research sites participating on the same study to submit a single ethics review. To help users learn how to use the platform, we’ve developed a series of manuals and video tutorials.
Access resources for using QuickSTART, an online platform that helps clinical trials sites and industry sponsors establish standardized processes to improve efficiency and achieve a 90-day overall start-up time for clinical trials.
The Ontario Leadership Table published a new position paper outlining their top priorities for transformative change in the clinical trials environment.
In this session, we’ll cover the foundation of how to establish a metrics program — focusing on the Who, What, Where, When, Why, and How. Metrics are the cornerstone for measuring success, and anyone can become a metrics master (promise!). We’ll share our experience establishing a metrics program, discuss lessons learned, go over best practices, and share case scenarios that highlight the value we have gained from leaning in to the numbers.
Yvan Lamoureux, CEO and Founder of ResearchMetrix discusses how going beyond protocol targets and gaining a better understanding of patient engagement produces more positive patient outcomes. Learn why digital online recruitment tactics have become fragmented and require a balanced, integrated, multi-channel approach. Yvan will describe how pre-screening for trials differs from practicing medicine and how to become more effective in recruitment efforts.
In part two of our series on clinical trial finance, Entela Zaffino and Jackie Anucha from The Hospital for Sick Children look at clinical trial unit finance oversight including:
In part one of our series on clinical trial finance, Shaherose Nanji & Shauna Kirk from The Hospital for Sick Children focused on clinical trial finance operations including:
Real data is often messy and incomplete, and its important to understand how to handle missing data. Database administrator and analyst, Chris Battiston, discusses causes and types of missing data, how to reduce missing data during the design phase, data quality checks and how to handle missing data during those checks/analyses.
Panelists Emily Taylor (UHN), Greg Staios (Seneca College), and Margaret Molnar (Hoffman-La Roche Limited) discuss different paths and careers in research, share their own experiences and tips, and address audience questions.
As a result of the pandemic there has been a desire to shift many paper-based processes to an electronic format. Join us on September 13th with Megan Reilly, Clinical Research & Compliance Officer at the University of Ottawa Heart Institute (UOHI), to discuss the implementation of regulatory eBinders. Megan will be speaking on challenges, solutions, implementation, pros, and cons of regulatory eBinders.
Lauren Gogo, Manager of Research Contracts at Hamilton Health Sciences Corporation, discusses clinical trial agreement basics, best practices, tools, and different ways to approach a contract.
Jill Beckley from the Division of Haematology/Oncology Clinical Trials Support Unit at the Hospital for Sick Children shares how cancer trials have evolved due to the COVID-19 pandemic. Jill discusses best practices for current processes, how to improve quality and increase efficiency, and eliminating silos between research and clinical groups.
Research Ready Advisory Group Member Rosemarie Clarke shares best practices, tips, and practical solutions for decentralized clinical trials. Rosemarie discusses REB applications, recruitment strategies, and digital integration.
Lanre Tunji-Ajayi of the Sickle Cell Awareness Group of Ontario (SCAGO) discus diversity in research. Major themes include the importance of diversity in clinical trials, steps towards building trust and awareness of clinical trials in specific communities, and practical tips on working with diverse communities participating in research.
Speakers from Southlake and the Population Health Research Institute share their experience and learnings using remote consent within a DCT study model, focusing on rapport with participants, privacy, and processes used.
Panelists from Princess Margaret Cancer Centre, CHEO Research Institute, and Lawson Health Research Institute discuss tips and tricks for Health Canada inspection readiness.
Ellen Morrison and Stephanie Badour share some best practices for the preparation and execution of a remote monitoring visit. Whether your site has full access EMR, uses redacted documents or video conference platforms, there are ways to improve the efficiency of this monitoring approach that can be easily adopted. Ellen and Stephanie have been working together in the peer-to-peer monitoring program and more recently using remote monitoring, and are going to share their best tips and tricks with you in this session.
Sarah Best, Clinical Trials Research Manager for the Cognitive Clinical Research Group (CCRG) at Parkwood Institute, discusses how to assess a clinical trial budget. She helps identify important cost elements to consider for clinical trial budgeting and provides techniques and tools to assess a complete trial budget with confidence.
Dawn Richards, founder of Five02 Labs Inc. and Director of Patient and Public Engagement at CTO, discusses how working with people who live with conditions brings different perspectives to the work. Dawn provides practical guidance on how to start the process and where to find helpful resources.
Geetha Sanmugalingham, Certified Clinical Research Professional, discusses REDCap: a secure web application for building and managing online surveys and databases. Geetha shares how REDCap can be used to design a data capture form specific to your research study and how to effectively take the collected data and present it in a report using it for analysis, quality improvement, audits, and more.
TransCelerate BioPharma collaborates across the global biopharmaceutical research and development community to identify, prioritize, design, and facilitate the implementation of solutions designed to drive the efficient, effective and high-quality delivery of new medicines.
CTTI is a public-private partnership co-founded by the U.S. FDA and Duke University. CTTI’s mission is to develop and drive adoption of practices that will increase the quality and efficiency of clinical trials.
The Network of Networks (N2) is a not-for-profit incorporated organization and an alliance of Canadian research networks and organizations working to enhance national clinical research capability and capacity. It provides educational resources and tools in clinical research.
The CITI-Canada Program offers comprehensive courses on a variety of research related matters and is accessible to N2 members/organizations.
The Good Clinical Practice (GCP) course is designed to prepare research staff for the conduct of clinical trials with human participants. The 12 modules included in the course are based on ICH GCP Principles, confidentiality and protection of study participants enrolled in substance use trials, and the Code of Federal Regulations (CFR) for clinical research trials in the U.S.
The online tutorial CORE-2022 (Course on Research Ethics) is an introduction to the Tri-Council Policy Statement (TCPS 2) for the research community. It focuses on the TCPS 2 ethics guidance that is applicable to all research involving human participants.
This is an introductory course consisting of 10 modules reflecting the ICH Guideline E6(R2): Guideline for Good Clinical Practice. The content is particularly directed at governmental regulatory reviewers and inspectors and is also applicable to other stakeholders including investigators, study teams, ethics committee members, research organizations and sponsors.
Link to CDRH Learn, the FDA’s Center for Devices and Radiological Health multi-media educational resource for industry. This page links to information in various formats that address medical device and radiation emitting product laws, regulations, guidance and policies.
The NCCIH Clinical Research Toolbox provides a Web-based information repository for investigators and staff involved in NCCIH-funded clinical research. The Toolbox contains templates, sample forms, and information materials to assist clinical investigators in the development and conduct of high-quality clinical research studies.
Template shared by UHN’s Cancer Clinical Research Unit to document Corrective Action and Preventive Action (CAPA) findings during an inspection.
Template shared by CHEO Research Institute to aid in preparing for an inspection. This detailed checklist is broken down into the different components that may be inspected.
Template shared by Lawson Research Institute to aid in preparing for an inspection. This detailed checklist is broken down into the different lead site components that may be inspected.
This template shared by UHN’s Cancer Clinical Research Unit is used to document daily inspection summaries including any applicable action items and requested documents. It may provide additional support during remote inspections to ensure the whole team is regularly updated.
Links to electronic versions of application and submission forms for drug products.
Links to electronic versions of application and submission forms for medical devices.
Links to electronic versions of application and submission forms for medical devices.
Basic information that was co-created with patient partners about finding trials and the clinical trial process
A search tool created with and by patient partners to help people look for a clinical trial
A database of privately and publicly funded clinical studies conducted around the world.
